个人简历

教育经历：

2010.01-2012.04，美国纽约大学医学院，环境医学研究所，联合培养博士生

2007.09-2012.07，武汉大学基础医学院，免疫学，博士（硕博连读）

2003.09-2007.07，山东大学，生物技术，学士

工作经历：

2018.09-至今， 皇冠正规娱乐平台，皇冠正规娱乐平台 副教授

2015.08-2018.08，解放军总医院第一附属医院，全军烧伤研究所， 副研究员

2012.08-2015.07，解放军总医院第一附属医院，全军烧伤研究所， 博士后

主讲课程

食品营养学、基础生物化学、生理学基础、免疫学原理与应用

主要研究领域

围绕全谷物营养健康作用，挖掘谷物新型功能因子，探究miRNA等非编码RNA参与新型功能因子营养健康作用的分子机制，揭示活性成分防控慢性疾病的分子机理等

主要学术成果（课题、论文、获奖、专利等）

承担的主要科研项目（限5项）：

1. 北京市科技新星计划，Z181100006218043，miR-30a调控骨骼肌细胞自噬而介导烧伤后骨骼肌消耗的机制研究，2018.01—2020.12, 主持

2. 国家自然科学基金面上项目，81471873，miR-628促进烧伤后胰岛素抵抗和骨骼肌消耗的机制研究，2015.01—2018.12, 主持

3. 北京市自然科学基金面上项目，7172210，miR-181c调控TLR4/NF-κB通路参与烧伤大鼠脓毒症发生的机制研究，2017.01—2019.12, 主持

4. 北京市自然科学基金青年项目，7144250，miR-194参与烧伤后胰岛素抵抗调控的分子机制研究，2014.01—2015.12, 主持

5. 中国博士后基金面上项目，2013M533220，TNFα参与烧伤后骨骼肌蛋白高分解代谢的机制研究，2013.08—2015.08, 主持

发表的代表性论文（限10篇）：

1. Yu Yonghui^#; Zhang Jingjie^#; Wang Jing*; Sun Baoguo. MicroRNAs: The novel mediators for nutrient-modulating biological functions. Trends in Food Science and Technology, 2021, 114: 167-175.

2. Yu Yonghui^#; Gaine, Goutom Kumar^#; Zhou Linyue; Zhang Jingjie*; Wang Jing*; Sun Baoguo. The classical and potential novel healthy functions of rice bran protein and its hydrolysates. Critical Reviews in Food Science and Nutrition, 2021, 1-13.

3. Zhang Jingjie, Yu Yonghui*, Wang Jing*. Protein Nutritional Support: The Classical and Potential New Mechanisms in the Prevention and Therapy of Sarcopenia. J Agric Food Chem. 2020; 68(14): 4098–4108.

4. Yu Yonghui#, Zhang Jingjie#, Wang Jing*, Sun Baoguo. The anti-cancer activity and potential clinical application of rice bran extracts and fermentation products. RSC Advances, 2019; 9(6): 80060-18069.

5. Zhao Fen, Yu Yonghui*, Liu Wei, Liu Xinqi*, Liu Lingying, Yin Huinan. Small Molecular Weight Soybean Protein-Derived Peptides Nutriment Attenuates Rat Burn Injury-Induced Muscle Atrophy by Modulation of Ubiquitin-Proteasome System and Autophagy Signaling Pathway. J Agric Food Chem. 2018; 66(11): 2724-2734.

6. Yu Yonghui, Yang Longlong, Han Shaofang, Wu Yushou, Liu Lingying, Chang Yang, Wang Xiaoteng, Chai Jiake*. MIR-190B Alleviates Cell Autophagy and Burn-Induced Skeletal Muscle Wasting via Modulating PHLPP1/AKT/FOXO3A Signaling Pathway. Shock, 2019, 52(5): 513-521..

7. Yu Yonghui, Jin Honglei, Xu Jiheng, Gu Jiayan, Li Xin, Xie Qipeng, Huang Haishan, Li Jingxia, Tian Zhongxian, Jiang Guosong, Chen Caiyi, He Feng, Wu Xue-Ru, Huang Chuanshu. XIAP Overexpression Promotes Bladder Cancer Invasion in Vitro and Lung Metastasis in Vivo via Enhancing Nucleolin-Mediated Rho-GDIβ mRNA Stability. Int J Cancer, 2018; 142(10): 2040-2055.

8. Yu Yonghui #, Li Xiao #, Liu Lingying #, Chai Jiake *, Zhang Haijun, Chu Wanli, Yin Huinan, Ma Li, Duan Hongjie, Xiao Mengjing. miR-628 promotes burn-induced skeletal muscle atrophy via targeting IRS1. Int J Biol Sci. 2016; 12(10):1213-1224.

9. Li Xiao#, Liu Lingying#, Yang Jing#, Yu Yonghui#, Chai Jiake*, Wang Lingyan, Ma Li, Yin Huinan. Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation. Ebiomedicine. 2016; 8:72–82.（ESI高被引论文）

10. Yu Yonghui, Zhang Dongyun, Li Jingxia, Zhang Min, Wan Yu, Gao Jimin, Huang Chuanshu*. NF-κB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1. Oncogene, 2014; 33(8): 996-1005.